Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.
不久的将来，截瘫囚犯马特·米尔斯会见了Satoshi Telefair Industries的“董事会”，后者感谢他加入该项目。迫于压力，米尔斯答应让他重新走路，他同意做志愿者。他被注射了一种合成纳米材料，然后窒息而死，结果醒来时双腿恢复了功能，却独自一人躺在一个钢制的牢房里，这是一个实验装置的第一个轮辐——轮子。一系列袭击者对米尔斯的身体造成大量伤害，折磨他的心灵，然而这种合成纳米材料不仅恢复了他受损的器官，还重新激发了他的力量。这个实验可能是为了杀人，但米尔斯决心要活下来——在董事会第一次找到女儿之前，回到女儿身边。
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